Fatty acid metabolism in hepatocytes cultured with hypolipidaemic drugs. Role of carnitine
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چکیده
منابع مشابه
Fatty acid metabolism in hepatocytes cultured with hypolipidaemic drugs. Role of carnitine.
The direct effects of clofibrate analogues on carnitine acyltransferase activities and fatty acid metabolism were studied in cultured hepatocytes. Rat hepatocytes cultured with bezafibrate or ciprofibrate (0.1-10 micrograms/ml) for 48 h had increased activities of carnitine acetyltransferase (CAT; 4-6-fold) and carnitine palmitoyltransferase (CPT; 12-34%). The increase in CAT was higher in hepa...
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BACKGROUND NEFA plays numerous roles in the metabolism of glucose, lipids, and proteins. A number of experimental studies have shown that NEFA may have an important role in fatty acid metabolism in the liver, especially in dairy cows that experience negative energy balance (NEB) during early lactation. METHODS In this study, using fluorescent quantitative RT-PCR, ELISA, and primary hepatocyte...
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This study investigated the role of the chicken liver fatty acid-binding protein (L-FABP) gene in lipid metabolism in hepatocytes, and the regulatory relationships between L-FABP and genes related to lipid metabolism. The short hairpin RNA (shRNA) interference vector with L-FABP and an eukaryotic expression vector were used. Chicken hepatocytes were subjected to shRNA-mediated knockdown or L-FA...
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متن کاملThe role of carnitine and carnitine acyltransferase in biological acetylations and fatty acid synthesis.
The effect of (-)-carnitine on the conversion of citratel-r4C and pyruvate-2J4C to 14C02 and either 14C-fatty acids or 14C-acetylsulfanilamide was studied in pigeon liver homogenates. Carnitine stimulated the conversion of pyruvate-2-W to fatty acids and acetylsulfanilamide, but had no effect on citrate. In the fasted state both fatty acid synthesis and citrate cleavage enzyme activity were dec...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1988
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2530161